Temporal and spatial origins models of neural subtypes in nuclei septum

来源 :中国神经科学学会第九届全国学术会议暨第五届会员代表大会 | 被引量 : 0次 | 上传用户:caikuairen
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  Septum has very important roles in connections between forebrain and middle brain.Since its neurons project into hippocampus, it make great role in the regulation of learning and memory.In the past decades, septum has been separately defined into lateral septum (LS) and medial septum (MS) by the anatomical differences.In our recent work, we identified two markers, sp8 and sox6, to distinguish LS with MS.In addition, LS can subdivide into dorsal (LSD), medial (LSI) and ventral (LSV) parts.By using markers we proved that MS neurons are also found similarly in the Diagonal Bind of Broca (DBB).Most of the neurons in LSI express GABA-ergic marker calbindin (CB), which express Sp8, some of them express Nkx2.1.Neurons in LSV express GABA-ergic marker calretinin (CR), which colabelling with Sp8, Pax6,and Emxl.Neurons in MS/DBB may have diverse origins, GABA-ergic marker PV express sox6, Chat express Nkx2.1 but not Sox6, nNOS express both Nkx2.1 and Sox6.By BrdU fate mapping, we found MS neurons born at fist, from Embyronic (E) 10.5 to 12.5.While LS neurons born later from E12.5 to E14.5.By using electroporation (ET) reporter plasmid, combined with Cre-Loxp technology, we specifically followed the septal routes of the progenitors of Emx 1-lineage, directly verified the embryonic dorsal part origins of septum.Similarly, we can explore the multiple origins model: medial, ventral, and the ventral-caudal part origins.In sum, we are unraveling the diversity of septums neurons, which is the result of the different temporal and spatial origins.
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