Background: Refractory acute graft versus host disease (aGVHD) is one of the major causes of death after allogenetic haematopoietic stem cell transplantation (allo-HSCT).Aims: This study evaluated the
Background: Epstein-Barr virus (EBV) infection may result in a spectrum of diseases in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT), including fever, post-transplant ly
Background: Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication that follows solid organ transplantation or allogeneic hematopoie
Background: Adult T lymphoblastic lymphoma is an aggressive form of non-Hodgkin lymphoma occurring in predominantly adolescent and young adult men.High-dose chemotherapy followed by autologous or allo
Background.Myeloid sarcoma(MS) is a tumor formed by extramedullary accumulation of myeloblasts or immature myeloid cells,found in 2％-8％ of patients with acute myeloid leukemia (AML).MS may develop bef
Background.Allo-hematopoietic stem cell transplantation (HSCT) has been considered a prior therapeutic option in young patients with severe aplastic anaemia(SAA).The conditioning regiment often consis
Objective: To investigate the effects of nicotine on the ultrastructure, proliferation, apoptosis and protein expression in human umbilical cord mesenchymal stem cells (MSCs).Methods: Human umbilical
目的：构建BCR-ABL融合基因激酶区T315I突变型和野生型质粒.材料和方法：一、材料：血液标本为在我院确诊的CML患者伊马替尼治疗2年后发生耐药，经基因测序证实存在T315I点突变的患者外周血.二、方法：1.取患者血液标本通过分离白细胞提取RNA；2.应用第一链cDNA合成试剂盒对RNA逆转录获得cDNA；3.针对T315I突变区域设计特定PCR引物，通过PCR反应大量扩增目的DNA片段；4、
目的：我们前期研究发现粒细胞集落刺激因子(G-CSF)动员可能影响TRGV和TRDV亚家族(γδT细胞的T细胞受体(TCR)亚家族)的TCR谱系分布和克隆性，且G-CSF动员后TRDV1亚家族表达的稳定性与移植受者移植物抗宿主病(GVHD)的低发生率呈正相关。
毛细胞白血病(hairy cel leukemia,HCL)也称多毛细胞白血病,是一种临床少见的B淋巴细胞恶性增生性血液系统肿瘤,约占白血病的2-3％[1,2],本病临床进展缓慢,主要表现为全血细胞减少,脾脏肿大,淋巴结肿大不明显,外周血和骨髓中均有特异的胞质毛样突起的"多毛"B淋巴细胞,并常伴有骨髓纤维化等[3].本病常见的并发症为细菌感染,亦有可能合并肺孢子菌肺炎、Sweet综合征等.