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The aims of present study were to investigate effects of optogenetic activation of anterior cingulate cortex (ACC) on heroin self-administration, heroin seeking behavior induced by cues or heroin priming and learning and memory in rats.The rats in ACC optogenetic activation group were microinjected with 1 μl pAAV-CaMK Ⅱ α-hChR2-EYFP into ACC(AP: +2.7mm, ML: 0.5mm, DV: 2.5mm), then implanted optical fiber 0.5 mm above site of microinjection.