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Purpose:Toevaluatetheprevalenceofcoronaryarterydisease(CAD)inpatientsafteracuteischemicstroke(AIS)andto determinetheclinicalandimagingfeaturespronetocombingCADbyusinghigh-pithcombinedcoronaryandcarotid-cerebral CTAwithathird-generationdual-sourceCTscanner. Methods:77patientswithin2weeksafterAISunderwentprospectiveECGtriggeredhigh-pitchcombinedcoronaryandcarotidcerebral CTA.Triggertimewassetat35%or60%(dependingonheartrates)R-Rinterval.Curvedplanarreformatting(CPR), maximumintensityprojection(MIP),multiplanarreformatting(MPR)andvolumerendering(VR)imageswereusedtoevaluate thecarotid,cerebral,andcoronaryarteries.Obstructionorstenosisgreaterthan50%wasclassifiedassignificantstenosis. Coronaryarterycalciumscores(CACS),aortaarchcalciumscores(AACS),carotidbifurcationcalciumscores(CBCS),carotidsiphon calciumscores(CSCS)werequantifiedsemi-automaticallybycalculatingtheAgastonscoreonnon-enhancedimages.Theplaque typeandplaquethicknessofaortaarch,carotidbifurcationandcarotidsiphonwererecorded.Themainriskfactorssuchasage, gender,hypertension,dyslipidemia,diabeteswerealsoassessed. Results: 77subjects(58male,19female,meanage59.4±10.8yrs)wereincluded,ofwhom51.9%(40)hadsignificantstenosisof carotidorcerebralarteries.Themeandose-lengthproduct(DLP)was125.9±30.7mGy×cmforthewholeexaminationandthe contrastvolumewas40ml.22subjects(27.3%)hadsignificantstenosisofcoronaryarteries(atleastonevessel).Theextentof CADwassignificantlycorrelatedwiththestenosisdegreeofextracranialarteries,CACS,AACSandtheplaquethicknessofaorta arch(p<0.05).LogisticregressionanalysisshowedthattheriskfactorsofCADinAISpatientswerehypertension,dyslipidemia andCACS. Conclusions:High-pitchcombinedcoronaryandcarotid-cerebralCTangiographyisvaluablefordetectingconcomitantCADin AISpatients.Someextra-coronaryimagingfeaturesarepredictabletoCAD.