【摘 要】
：
目前临床研究表明,有效的病因治疗可以逆转肝纤维化及肝硬化,但仍存在诸多问题.首先,诊断方面,肝纤维化逆转的评估方法有待完善.其次,治疗方面尚缺乏特异性的抗纤维化药物.此
【出 处】
：
北京细胞生物学会2015年学术大会
论文部分内容阅读
目前临床研究表明,有效的病因治疗可以逆转肝纤维化及肝硬化,但仍存在诸多问题.首先,诊断方面,肝纤维化逆转的评估方法有待完善.其次,治疗方面尚缺乏特异性的抗纤维化药物.此外,临床转归方面,肝纤维化逆转是否可以改善患者的临床硬终点仍需大规模临床研究证实.针对以上问题,未来需进一步探讨用于评估肝纤维化逆转的无创模型及全定量评估方法,明确纤维化相关的分子机制及信号通路以研发特异性抗纤维化药物,开展大规模的肝纤维化临床研究,以明确肝纤维化逆转与患者肝硬化失代偿、肝癌发生率及病死率的关系.
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