SPARC Enhances Muscarinic Receptor-Stimulated Insulin Secretion in Mouse Islet Beta Cells through Do

来源 :第八届湘雅国际糖尿病免疫学论坛 | 被引量 : 0次 | 上传用户：z315659288

【摘要】

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【作者】

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Fengli He Li Hu Luo Hai Yabin Li Yan Luo Zhiguang Zhou Feng Liu Yan-Shan Dai

【机构】

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Metabolic Syndrome Research Center,Second Xiangya Hospital,Central South University,Changsha,Hunan 4

【出处】

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第八届湘雅国际糖尿病免疫学论坛

【发表日期】

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2013年4期

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Objective SPARC (Secreted Protein, Acidic and Rich in Cysteine) is a secreted extracellular matrix protein that is involved in the development, remodeling and tissue repair by modulating cell-cell and cell-matrix interactions.Integrin beta3 is a SPARC receptor.Blood SPARC level is increased in early Type 2 diabetes patients.It is known that acetylcholine is released from intrapancreatic nerve endings and stimulates insulin secretion through M3 muscarinic receptor in beta cells during food ingestion.The function of SPARC in beta-cells is unknown.Hence, we investigated the regulation of SPARC in Min6 cells and potential roles of SPARC in insulin signaling in Min6 cells and insulin secretion in mouse islet cells.

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SPARC Enhances Muscarinic Receptor-Stimulated Insulin Secretion in Mouse Islet Beta Cells through Do

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