【摘 要】
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Drug delivery systems (DDS) have appeared as a promising and reliable approach to delivering potent drugs to the site of action precisely and timely,in which polymeric nanosystems including micelles,n
【机 构】
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Freie Universit(a)it Berlin,Institut für Chemie und Biochemie,Takustraβe 3,14195 Berlin,Germany
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Drug delivery systems (DDS) have appeared as a promising and reliable approach to delivering potent drugs to the site of action precisely and timely,in which polymeric nanosystems including micelles,nanoparticles,and nanogels,have been mostly investigated,due to their prolonged circulation time,enhanced accumulation in the tumor sites via the enhanced permeability and retention (EPR) effect,decreased adverse effects,and improved drug tolerance [1].As compared to other nanosystems,nanogels with internally cross-linked 3D structures are highly interesting for controlling drug delivery at the target site in fast response to external stimuli,as well as improving the drug bioavailability.Taking the advantage of the high redox potential in cytoplasms and nuclei of cancer cells which contain a 100 to l000-fold higher concentration of reducing glutathione (GSH) tripeptide than body fluids and extraeellular milieu (0.5-10 mM versus 2-20 μM GSH),reduction-sensitive nanogels have recently been designed and exploited for active intracellular release of various potent chemotherapeutics.
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