【摘 要】
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Alkylating agents are powerful first-line therapeutics for the treatment of malignant gliomas and metastatic melanomas.Although they alkylate DNA at several sites,the minor product O6-alkylguanine rep
【机 构】
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Department of Toxicology University Medical Center Germany
论文部分内容阅读
Alkylating agents are powerful first-line therapeutics for the treatment of malignant gliomas and metastatic melanomas.Although they alkylate DNA at several sites,the minor product O6-alkylguanine represents the major cytotoxic DNA lesion,activating the apoptotic,autophagic and senescence pathway.
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