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目的:探讨独活对AD和VD模型大鼠免疫炎性损伤的调节作用。方法:采用Aβ1–40蛋白所诱发AD模型、双侧颈总动脉持久结扎塑造VD模型,ELISA法测定血清IL-4、TNF-α含量。结果:独活治疗VD后潜伏期下降(P<0.05),AD和VD模型组IL-4含量下降(P<0.01),TNF-α含量升高(P<0.01),独活可显著改善上述指标的水平(P<0.01)。结论:独活对AD和VD模型大鼠免疫炎性损伤具有调节作用,尤其对VD的治疗作用更明显。
Objective: To investigate the regulatory effect of solo-live on immune inflammatory injury in AD and VD rats. Methods: AD model induced by Aβ1-40 protein and persistent ligation of bilateral common carotid artery were used to establish VD model. Serum levels of IL-4 and TNF-α were measured by ELISA. Results: Induction of VD decreased the latency (P <0.05), the levels of IL-4 in AD and VD groups decreased (P <0.01) and the content of TNF-α increased (P <0.01). Conclusion: ADHD has immunoregulatory effects on AD and VD rats, especially in the treatment of VD.