【摘 要】
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Phosphatidylinositol 3-kinase (PI3K) signaling pathway is frequently deregulated in human malignancy, making it an attractive target for cancer treatment.However, drug resistance often develops in tar
【机 构】
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Institute of Cancer Stem Cell Dalian Medical University China
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Phosphatidylinositol 3-kinase (PI3K) signaling pathway is frequently deregulated in human malignancy, making it an attractive target for cancer treatment.However, drug resistance often develops in targeted cancer therapy and leads to treatment failure.To uncover mechanisms of resistance to PI3K inhibition, we generated a mouse model of breast cancer conditionally expressing human PIK3CA (H1047R), a mutant form of PIK3CA.
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