β-arrestins is a kind of important adaptor protein and signal transduction protein found in the purification process of β-adrenergic receptor kinase (β-ARK).β-arrestins can selectively bind to the phosphorylated activated form of G protein-coupled receptors (GPCR), thereby blocking further G protein activation, and regulate a series of signaling pathway according to present status of research.Fibrosis is defined by the overgrowth, hardening, and scarring of various tissues and is attributed to excess deposition of extracellular matrix (ECM) components including collagen, currently no treatment modality would alleviate these symptoms effectively.A large number of studies have shown that β-arrestins play an important role in the process of fibrotic diseases, involved in inflammatory response and excess deposition of ECM.In this review, we will discuss the research status and development prospects of β-arrestins-mediated fibrotic diseases.