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  5. Demethylation of Cxcr3 gene promoter and upregulation of CXCL10 after spinal nerve ligation contribu

Demethylation of Cxcr3 gene promoter and upregulation of CXCL10 after spinal nerve ligation contribu

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：xujie880112
【摘 要】
：
DNA methylation has been implicated in the pathogenesis of chronic pain.Here we investigated how chemokine receptor CXCR3 is regulated by DNA methylation and its contribution to neuropathic pain induc
【作 者】
：
Chun-Hua Li Bao-Chun Jiang Li-Na He Xiao-Bo Wu Hui Shi Wen-Wen Zhang Jun Gu De-Li Cao Yong-Jing Gao 
【机 构】
：
Pain Research Laboratory,Institute of Nautical Medicine,Jiangsu Key Laboratory of Inflammation and M
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
CXCR3 CXCL10 DNMT3b C/EBPα epigenetic neuropathic pain 
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　　DNA methylation has been implicated in the pathogenesis of chronic pain.Here we investigated how chemokine receptor CXCR3 is regulated by DNA methylation and its contribution to neuropathic pain induced by spinal nerve ligation(SNL).SNL increased Cxcr3 mRNA and protein expression in the neurons of spinal cord.Meanwhile,the CpG(cytosine–phosphate–guanine)island in the Cxcr3 gene promoter region was demethylated,and the expression of DNA methyltransferase 3b(DNMT3b)and its binding with Cxcr3 promoter were downregulated in mice with neuropathic pain.
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