Objective:To investigate the prevalence and determinants of hyperuricemia in Chinese type 2 diabetes mellitus (T2DM) patients with central obesity.Methods:A multicentric hospital-based cross-sectional study was carried out in Guangdong Province between August 2011 and March 2012.In each hospital,Chinese T2DM patients with central obesity,whose age over 20 years,whose serum uric acid level was measured,who had lived in Guangdong Province for ≥ 1 year,were recruited in this study.Hyperuricemia was defined as serum uric acid > 420 μmol/L in males and > 360 μ mol/L in females.Binary logistic regression was used to assess associated risk factors of hyperuricemia.Results:A total of 2917 T2DM patients with central obesity were included in this study,the overall prevalence of hyperuricemia was 32.6% (36.1% of females,28.4% of males).Binary logistic regression analysis demonstrated that female gender(=OR=:1.576,95% con□dence interval [CI]:1.231,2.018),high BMI (OR:1.228,95%CI:1.094,1.379) and waist circumference (OR:1.135,95%CI:1.009,1.276),hypertension (OR:1.603,95%CI:1.263,2.035),high total cholesterol (OR:1.133,95%CI:1.002,1.281),and triglycerides (OR:1.134,95%CI:1.069,1.203),low HDL-cholesterol (OR:0.820,95%CI:0.677,0.995) and low estimated glomerular filtration rate (eGFR) (OR:0.840,95%CI:0.815,0.866) were risk factors associated with hyperuricemia.Conclusions:Hyperuricemia is prevalent in Chinese T2DM patients with central obesity and is siginificantly positive associated with female gender,cardiovascular risk factors such as obesity,hypertension and dyslipidemia,as well as low eGFR.