Genetic overactive Slack channel (KCNT1) mutants lead to epilepsy by two different mechanisms

来源 :长三角地区神经科学论坛暨浙江省神经科学学会2014年年会 | 被引量 : 0次 | 上传用户：wuguiyuan2009

【摘要】

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【作者】

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Qiong-Yao Tang Fei-Fei Zhang Jie Xu Ran Wang Xiao-lu Yu Zhe Zhang

【机构】

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Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical College,Xuzhou,Jiangsu Province,CHI

【出处】

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长三角地区神经科学论坛暨浙江省神经科学学会2014年年会

【发表日期】

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2014年5期

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So far,12 genetic mutants of sodium-activated potassium channel (KCNT1,Slack) had been found in severe early-onset epilepsy patient by whole genome sequence.However,how the biophysical property of these mutated Slack channel been changed and the underlying mechanism that leads to epilepsy remain unknown.

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Genetic overactive Slack channel (KCNT1) mutants lead to epilepsy by two different mechanisms

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