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  5. Nucleosome occupancy patterns around different gene regulatory sites

Nucleosome occupancy patterns around different gene regulatory sites

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：liongliong486
【摘 要】
：
　　The basic unit of chromatin structure is the nucleosome, consisting of histone octamers wrapped in 147 base pairs of DNA.Eukaryotic genomic DNA is assembled
【作 者】
：
孙啸 聂玉敏 黄焕 刘宏德 
【机 构】
：
生物电子学国家重点实验室,生物科学与医学工程学院,东南大学,南京,210096
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年10期
【关键词】
：
Nucleosome Transcription Occupancy pattern Gene regulatory site. 
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论文部分内容阅读
　　The basic unit of chromatin structure is the nucleosome, consisting of histone octamers wrapped in 147 base pairs of DNA.Eukaryotic genomic DNA is assembled into nucleosomes and is further packaged into chromatin to achieve high compaction.Nucleosome positioning plays an important role in gene regulation, such as the initiation of transcription, alternative splicing and the termination of transcription.The mechanism behind these regulations is that nucleosomes can compete with protein factors and directly affect the accessibility of transcription factor and other processing factors to the DNA sequences.
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