Cytosolic delivery of functional antibodies is urgently required for live-cell imaging and protein-based therapeutics,but constantly plagued by the need of chemical/genetic modifications and endosomal
Pyrrole-imidazole Polyamide(PIP)[1-2] can specifically bind in the minor-groove of DNA,which has been demonstrated in a variety of biological applications,including anti-cancer activity,regulation of
Signal transduction plays a vital role in cellular functions.It is well known that reversible tyrosine phosphorylation is also an early step in the transduction of many types of signals in multicellul
The human ClpP proteolytic complex(HsClpP)is a serine protease located in the mitochondrial matrix and participates in the maintenance of mitochondrial protein quality by degrading misfolded protein [
A number of multimodal agents have been developed for tumour imaging and diagnosing,however,most of them cannot be used to study the detailed physiological or pathological changes in living cells at t