tumorigenesis相关论文
人类微小RNA（microRNA,简称miRNA）通过和Ago2蛋白结合形成RISC复合物（RNA-induced silencing complex）,介导mRNA降解和抑制mRNA翻译,发......
Insights into the Pathogenesis of Preeclampsia Based on the Features of Placentation and Tumorigenes
...
...
...
核转录因子红细胞系-2p45 （NF-E2）相关因子-2 (nuclear factor erythroid-2p45-related factor2，Nrf2)介导的细胞适应性氧化应激反应......
...
肿瘤发生是一个多步骤过程.绝大多数人肿瘤由产生了系列相继变化的单一细胞形成.这些变化导致细胞有丝分裂信号或生长控制的细微异......
CTNNB1 (or beta-catenin) is regarded as a central effecter in molecules of the wingless/Wnt signalling pathway. It is a ......
miRNAs are a class of small, ~22nt, non-coding RNAs that negatively regulate gene expression at the post- transcriptiona......
Reactive oxygen species (ROS) are molecules or ions formed by the incomplete one-electron reduction of oxygen. Ofinteres......
Appropriately controlled gene expression is fundamental for normal growth and survival of all living organisms.In eukary......
A major portion of the mammalian genome is transcribed to produce large numbers of noncoding RNAs(ncRNAs).During the pas......
The link between chronic inflammation and colorectal cancer has been well established. The events proceeding along tumor......
Recently,the research group led by Prof.Wu Mian and Pro~Mei Yide from University of Science and Technology of China has ......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
目的 研究高迁移率蛋白A2(HMGA2)和血管内皮生长因子(VEGF)在膀胱尿路上皮癌中发生及复发中的表达及其意义.方法应用免疫组织化学......
目的探讨三磷酸腺苷酶家族蛋白2（ATAD2）在不同病变肝组织中的表达情况及其临床应用价值。方法用免疫组织化学法检测ATAD2在60例肝细......
Background Very recent studies revealed that obstructive sleep apnoea (OSA) is a contributor of the increased incidence ......
Objective:Polycystic kidney disease (PKD) is the major cause of kidney failure and mortality in humans.It has always bee......
The genome of cells is constantly challenged by DNA damages from endogenous metabolism and environmental agents. These d......
胃癌是恶性肿瘤中造成癌症相关死亡的主要原因之一，其发病机制、化疗耐药、早期诊断及预后判断等诸多问题的研究尚不明确。长非编码......
Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and ther......
Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and dru
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Low-density lipoprotein receptor-related protein 1(LRP1,also known as CD91),a multifunctional endocytic and cell signali......
Synergistic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and N-nitrosodiethylamine tion Cell Malig
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
表观遗传指不改变DNA序列的基因表达改变,是多细胞真核生物的重要生物学现象.在个体发生过程中,干细胞一旦分化为某种分化细胞,该......
随着肿瘤干细胞(CSC)假说的出现,肿瘤研究领域经历了一次革命,人们从新的角度认识和研究肿瘤.面对肿瘤难以根治这一难题,CSC理论带......
SM22α是一种重要的细胞骨架相关蛋白,近年来发现它在细胞转化、分裂、黏附、转移中都发挥了重要作用.研究表明它在乳腺癌、大肠癌......
对肝癌组织和肝硬化组织进行抑制性消减杂交在肝癌中获得的高表达基因P02,它与TPT1基因高度同源,认为P02即TPT1.研究结果表明阻断......
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumor
Pyruvate kinase catalyzes the rate-limiting final step of glycolysis,generating adenosine triphosphate (ATP) and pyruvat......
肿瘤的发生发展是一个涉及多基因改变、多信号通路的过程。 GRIM-19是一个新的细胞凋亡调控基因，其基因的突变、蛋白表达的缺失发生......
目的 探讨灰黄霉素在体内外对人前列腺癌PC-3细胞抗肿瘤作用的可能机制.方法 不同浓度(0、5、10、15、20、25 μg/ml)的灰黄霉素作......
目的 观察胃癌相关蛋白质POSTN在胃黏膜癌变过程中的表达与意义,为胃癌的早期诊断、病理分型与评估预后提供有价值的实验依据.方法......
Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and dru
The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistan......
A novel human gene spindlin1,encoding a protein localized in the cell nucleus and inducing NIH3T3 ce
A novel human gene, spindlin1, recently cloned in our laboratory, is highly expressed in the tissue of ovary cancer. To ......
Objective We examined alterations in the expression of tumorigenesis-related genes in the pituitary gland of rats expose......
AIM:To investigate alternative or subordinate pathways involved in colorectal tumorigenesis and tumor growth,possibly de......
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate......
Although we have made great progress in understanding tumor pathogenesis through studies on gene mutation and cancer ste......
Histone deacetylases (HDACs) play an important role in tumorigenesis. Inhibition of HDACs is considered as a potent stra......
Objective To review the leading roles of glioma stem cells (GSCs) and their sophisticated interactions with other cells ......
p73蛋白是p53蛋白家族的主要成员之一,其编码基因TP73与TP53基因高度同源。与p53蛋白类似,p73蛋白功能涉及细胞生命活动的各个方面......
虽然肿瘤学就像多细胞生物体一样衰老,但至今仍然有许多令人困惑的难题。本文提出并回答"肿瘤为什么存在?肿瘤从哪里来?肿瘤是什么......
现有的生物学方法不能证明细胞纠缠。数学模型、计算机模拟、机器学习、类器官模拟和活细胞示踪可能寻找到细胞纠缠的痕迹。数学方......
目的建立Trp53基因剔除小鼠模型。方法本研究拟通过基因工程技术建立Trp53基因剔除小鼠模型，通过RT—PCR、Western—blot等技术检测......
肿瘤的演化过程包括人类基因组中原癌基因相传、外来基因融入、线粒体DNA整合、驱动基因突变、蛋白质空间结构改变和肿瘤细胞传染......
目的探讨凋亡抑制蛋白（IAP）家族新成员Livin基因在骨肉瘤形成以及多药耐药过程中的作用。方法应用亚克隆技术构建Livin基因短发夹RNA......
肝再生磷酸酶（PRL）家族包含PRL-1、PRL-2、PRL-3三个亚型,是一种新型蛋白酪氨酸磷酸酶。研究表明其具有双特异性磷酸酶活性,通过参与......
肿瘤发生的问题始终没有明确答案，现有的资料提示肿瘤发生的理论模式包括微驱动基因突变、蛋白质失衡、中心体扩增、线粒体衰竭、干......
Hippo信号通路是在果蝇中发现的,能够调控器官大小,其功能异常会导致肿瘤发生。对Hippo通路及其上游调控因子进行了综述,并对其与......
