The Effects of Xenoestrogens or Phytoestrogens on the Androgen Receptor Binding and Prostate Cancer

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户:ziwen74
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  The androgen receptor (AR) plays a critical role in prostate cancer development and progression.The aim of this study is to use computer docking approaches to examine the interactions between the human AR and phytoestrogens (genistein, daidzein, and flavones), as well as xenoestrogens (bisphenol A, 4-nonylphenol, DDT, and DES).We established the predicted 3D structure of the AR and androgens, using the X-ray diffraction structure.Then we analyzed four xenoestrogens and three phytoestrogens, to AR, respectively.
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