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Mitochondria are crucial in the process of oxidative metabolism and apoptosis.Their morphology is greatly associated with the development of certain diseases [1].For specific and long-term imaging of mitochondrial morphology,we synthesized a new mitochondria-targeted near-infrared(NIR) fluorescent probe(TPE-Xan-In) by incorporating TPE with a NIR merocyanine skeleton(Xan-In).