【摘 要】
：
Neurotoxins are harmful to brain functions,especially interrupting memory processing.Hippocampal synaptic plasticity is supposed as models for memory processing.We and others reported the potential de
【机 构】
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Key Laboratory of Xin'an Medicine,Ministry of Education,Anhui University of Chinese Medicine,Hefei,
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Neurotoxins are harmful to brain functions,especially interrupting memory processing.Hippocampal synaptic plasticity is supposed as models for memory processing.We and others reported the potential detrimental effects of neurotoxins on hippocampal synaptic transmission and plasticity previously.In this study,we reported a new activity of 1-methyl-4-phenylpyridinium(MPP+)on metabotropic glutamate receptor 1/5(mGluR1/5)agonist,3,5-dihydroxyphenylglycine(DHPG)-induced hippocampal long-term depression(LTD).MPP+incubation blocked DHPGinduced hippocampal LTD in Schaffer collateral-CA1 synapses.This blockage was reversed by Calpain inhibitor pre-incubation.Biochemical results also showed that MPP+stimulated Calpain activation as evidenced by spectrin degradation.Interestingly,protein tyrosine phosphatase 1B(PTP1B)was degraded after MPP+incubation,which was blocked by Calpain inhibitor.Using a PTP1B antagonist,DHPG-induced LTD was also blocked.Taken together,our data suggested that MPP+activated Calpain-dependent PTP1B degradation to impair hippocampal LTD.
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