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NMDA 受体是中枢神经系统内的离子型谷氨酸受体,近年研究显示,该受体亦广泛分布于多种外周非神经组织,包括胰岛细胞。研究报道,NMDA 受体的过度激活对神经和非神经组织具有毒性作用。本室前期研究发现在整体动物水平上,NMDA 受体的过度激活可损伤小鼠胰岛的功能。
NMDA长时间处理小鼠胰腺β细胞MIN6导致细胞功能紊乱
【摘 要】
：
NMDA 受体是中枢神经系统内的离子型谷氨酸受体,近年研究显示,该受体亦广泛分布于多种外周非神经组织,包括胰岛细胞。研究报道,NMDA 受体的过度激活对神经和非神经组织具有毒性作用。本室前期研究发现在整体动物水平上,NMDA 受体的过度激活可损伤小鼠胰岛的功能。
【机 构】
：
中南大学基础医学院生理学系,长沙 410078 中南大学湘雅医院新生儿科,长沙 410078
【出 处】
：
中国生理学会第24届全国会员代表大会暨生理学学术大会
【发表日期】
：
2014年7期
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