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  5. MicroRNA-124 feedback regulates TNF-a production via decreasing protein stability in LPS-triggered m

MicroRNA-124 feedback regulates TNF-a production via decreasing protein stability in LPS-triggered m

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：jintianfuqin
【摘 要】
：
Aim: It was recently found miRNA-124, one of the most abundantly expressed miRNAs in the nervous system, could promotes microglia (tissue-resident macrophages in CNS) quiescence and suppresses experim
【作 者】
：
Yang SUN Qi LI Huan GUI Ding-feng SU Xia LIU 
【机 构】
：
Department of Pharmacology,School of Pharmacy, Second Military Medical University, Shanghai 200433,
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
micorRNA-124 macrophages TNF-α USP2 USP14 
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Aim: It was recently found miRNA-124, one of the most abundantly expressed miRNAs in the nervous system, could promotes microglia (tissue-resident macrophages in CNS) quiescence and suppresses experimental autoimmune encephalomyelitis (EAE) by deactivating macrophages.These findings prompted us to ask whether miR-124 is involved in regulation of the TLR activation in periphery macrophages.
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