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Distant metastasis is the major cause of nasopharyngeal carcinoma (NPC) treatment failure,while epithelial-mesenchymal transition (EMT) is a critical process for NPC invasionand metastasis.Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoproteinthat displays broad anti-tumor activity.In this study we report that PEDF is apparentlydecreased in 218 human NPC tissues compared with chronic inflammation of thenasopharynx by immunostaining.