【摘 要】
：
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of canonical NF-κB signaling in the Toll-like receptor (TLR)-and B-cell receptor (BLR)-mediated signaling pathways.However,
【机 构】
：
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Ac
【出 处】
：
全国农业生物化学与分子生物学第十四届学术研讨会
论文部分内容阅读
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of canonical NF-κB signaling in the Toll-like receptor (TLR)-and B-cell receptor (BLR)-mediated signaling pathways.However,functions of TANK in viral infection-mediated NF-κB activation remain unclear.Here we reported that TANK was cleaved by encephalomyocarditis virus (EMCV) 3C at the 197 and 291 glutamine residues, which depends on its cysteine protease activity.In addition, EMCV 3C impaired the ability of TANK to inhibit TRAF6-mediated NF-κB signaling.Interestingly, we found that several viral proteases encoded by foot and mouth diseases virus (FMDV), porcine reproductive and respiratory syndrome virus (PRRSV) and equine arteritis virus (EAV) also cleaved TANK.
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