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  5. Activation of the canonical Notch-signaling pathway mediates ischemic brain injury in mice

Activation of the canonical Notch-signaling pathway mediates ischemic brain injury in mice

来源 :中华医学会第22次全国麻醉学术年会 | 被引量 : 0次 | 上传用户：lxz119110
【摘 要】
：
The canonical Notch-signaling pathway (CNSP) is characterized by Y-secretase-dependent release of Notch intracellular domain from cell membrane and subsequent translocation to the nucleus, where it ac
【作 者】
：
Qianzi Yang Lihong Hou Hui Dong Xin Li Qiang Wang Hailong Dong Lize Xiong 
【机 构】
：
Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an,China
【出 处】
：
中华医学会第22次全国麻醉学术年会
【发表日期】
：
2014年11期
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The canonical Notch-signaling pathway (CNSP) is characterized by Y-secretase-dependent release of Notch intracellular domain from cell membrane and subsequent translocation to the nucleus, where it activates a transcriptional program in coupled with the essential transcriptional factor RBP-J1.Ablation or attenuation of Notch receptor expression can remarkably impact stroke outcome in rodents2,3, suggesting that Notch signaling may be an important determinant for ischemic brain injury.
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