Objectives: Based on the important changes in South Africa since 2009 and the Antiretroviral Treatment Guideline 2013 recommendations, we explored the cost-effectiveness of different strategy combinations according to the South African HIV-infected mothers prompt treatments and different feeding patterns.Study Design: A decision analytic model was applied to simulate cohorts of 10,000 HIV-infected pregnant women to compare the cost-effectiveness of two different HIV strategy combinations: (1) Women were tested and treated promptly at any time during pregnancy (Promptly treated cohort).(2) Women did not get testing or treatment until after delivery and appropriate standard treatments were offered as a remedy (Remedy cohort).Replacement feeding or exclusive breastfeeding was assigned in both strategies.Outcome measures included the number of infant HIV cases averted, the cost per infant HIV case averted, and the cost per life year(LY) saved from the interventions.One-way and multivariate sensitivity analyses were performed to estimate the uncertainty ranges of all outcomes.