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The radiation-induced bystander effect (RIBE) is the focus of rumor radiotherapy and radiobiological studies.As an oncogene,SKP2plays an important role in regulating the cell cycle and is frequently overexpressed in many types of tumors.SKP2 is a potential target gene forRIBE regulation.In the present study,we found a significantly negative correlation between SKP2 expression and micronucleus (MN) frequency (p<0.05) causedby RIBE.Thisresult was further confirmed by positive transfection,RNAi and rescue experiments (whereRNAi cells were transfectedwitha wobble mutant of SKP2 that isresistant to SKP2 siRNA).