Immunotherapy remains the subject of intense investigation in both adjuvant and advanced cancer, and attempts are being made to target defense mechanisms that blunt the effectiveness of host immune responses.However, there are few laboratory reports on homeopathic medicines in the medical literature; of those that have been published, the majority are clinical reports that have employed varied methodologies and yielded controversial, and often questionable, results.Despite this, a large number of patients continue to use such therapies.In Europe, homeopathy is the most frequent complementary and alternative medical therapy.Here we describe the results of experimental laboratory screening to verify the immunitary stimulation potential of peritoneal macrophages, bone marrow (BM) cells, and mesenteric lymph node lymphocytes (Ly) challenged with complex matrices, that follow Hahnemanns ancient homeopathic techniques.