【摘 要】
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Monocrotaline has been widely used for years to establish animal model of pulmonary hypertension.The molecular target underlying monocrotaline-induced pulmonary artery endothelial injury and pulmonary
【机 构】
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Department of Pathophysiology,School of Basic Medicine;Key Laboratory of Pulmonary Diseases of Minis
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Monocrotaline has been widely used for years to establish animal model of pulmonary hypertension.The molecular target underlying monocrotaline-induced pulmonary artery endothelial injury and pulmonary hypertension still remains unknown.The extracellular calcium-sensing receptor and particularly its extracellular domain richly contains histidine,tryptophan and cysteine and specific motif of CXXC,the potential structural bias for monocrotaline to bind to a protein.
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