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The preganglionic recurrent laryngeal motoneurons (PRLMs) dominate the neural control of almost all the intrinsic laryngeal muscles.These neurons receive noradrenergic projection,and systemic administration of α2-adrenoceptor (α2-AR) agonists reportedly causes augmented expiratory activity of the recurrent laryngeal nerve,glottis closure and laryngogenic apnea,however the central mechanisms remain unknown.