【摘 要】
：
Nociceptin/orphanin FQ (N/OFQ) plays an important role in a variety of physiological functions including learning and memory by exerting effects on different ion channels.Here we showed for the first
【机 构】
：
Department of Physiology,Harbin Medical Univesity-Daqing,Daqing 163319,China
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Nociceptin/orphanin FQ (N/OFQ) plays an important role in a variety of physiological functions including learning and memory by exerting effects on different ion channels.Here we showed for the first time that the effects of Ca2+-CaM-CaMKⅡ on the inhibition of IK by N/OFQ in acutely dissociated rat cerebral parietal cortical neurons.Our previous reported that N/OFQ inhibited delayed rectifier potassium current (IK) which were associated with PKC and ERK1/2 pathway.In this present study, we used the conventional whole cell patch-clamp technique.We wondered if Ca2+-CaM-CaMKⅡ is involved in the inhibitive effect of N/OFQ on IK.We found that W-7, a specific inhibitor for CaM, and KN-62, an inhibitor of CaMKII, attenuated the inhibitory effect of N/OFQ on the IK.These data suggest that the Ca2+-CaM-CaMKII pathway, at least in part, mediates the inhibitory effect of N/OFQ on the IK in acutely dissociated rat cerebral parietal cortical neurons.
其他文献
Objective: Latter kicksthe technology is horizontally in the Tae Kwon Do basic strokes in the single item and the combination technology important component, simultaneously is also the important means
In recent years, a number of potential synapto-nuclear protein messengers have been characterized that are thought to be involved in regulation of gene expression after induction of activity-dependent
Chronic heart failure (CHF) reduces protein expression of voltage-gated sodium (Nav) channels in rat nodose neurons.Here, we investigated involvements of mitochondrial superoxide and NFκB in CHFdecrea
U73122 is often used as a selective amino-steroid phospholipase C (PLC) inhibitor, which has been widely applied to exclude intracellular Ca2+ release from InsP3 sensitive storage sites from the trigg
Objective: In order to protect and treat the birth defects of neonate in emergency, promote the quality of man-kind, the environment must be protected effectively by law.In this article, how to protec
Chemotherapy can damage gonad function and sex hormone production.Bone marrow stem cells (BMSCs) transplantation can improve gonad function and reduce apoptosis of steroidogenic cells.The aim was to e
N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptor subtype in the central nervous system (CNS), which is also found in peripheral non-neural tissues recently, however, the influen
The G protein-coupled receptor kinases (GRKs) phosphorylate agonist occupied G protein-coupled receptors (GPCR) and desensitize GPCR-mediated signaling.A proteomic approach was used to screen interact
Aim of investigation: To study the effect of dexmedetomidine, a selective alpha 2 adrenergic receptor (α2-AR) agonist, on tetrodotoxin (TTX)-resistant Nav1.8 current in rat DRG neurons and investigate
The death receptor TNFR1 induces apoptosis in many tissues upon cross-linking by its ligand (TNF-α)and cotreatment with a protein synthesis inhibitor, cycloheximide, but a number of cancer cells resis