【摘 要】
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Internalization and sorting of agonist-stimulated receptors between divergent recycling and degradative membrane pathway are critical events determining the functional consequences of p-opioid recepto
【机 构】
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Pharmacology Research Center, Shanghai Medical College, Institutes of Brain Science, and State Key l
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Internalization and sorting of agonist-stimulated receptors between divergent recycling and degradative membrane pathway are critical events determining the functional consequences of p-opioid receptor (MOR).It has been generally accepted that phosphorylation is important for desensitization,internalization and down-regulation of MOR.However,in the view of results in HEK 293 cells,we observed that a mutant MOR,substituting the identified phosphorylation sites in the carboxyl terminal for alanine,exhibited agonist-induced internalization and recycling not significantly different from wild type MOR.The other truncated mutant MOR,missing the distal portion of carboxyl-termina containing these sites of regulatory phosphorylation,underwent decreased internalization and mostly sorted to lysosome for degradation.
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