Hexahydropyrrolo[2,1-a]isoquinoline and tetrahydropyrrolo[2,l-a]isoquinolin-3(2H)-one structures occur widely in natural products,which display remarkable antitumor,antibacterial,antiviral,and antioxidizing activities.Because of unique fused heterocyclic ring structures and diverse pharmacological activities,these alkaloids are very popular and attractive targets for synthetic organic chemists.However de novo construction of hexahydropyrrolo[2,1-a]isoquinoline and tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one structures in catalytic enantioselective manner is not known.