A Chiral Ruthenium-Monophosphine Catalyst for Asymmetric Addition of Arylboronic Acids to Aryl Aldeh

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户:heshang9994
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Chiral diarylmethanols are important building blocks for many antihistamine compounds or therapeutic agents such as (R)-orphenadrine, (S)-neobenodine, (S)-carbinoxamine, and bepotastine.catalytic methods for the syntheses of chiral diarylmethanols has thus gained significant interest [5] In this presentation, we will discuss our new progress in application of a novel ruthenium catalyst on the basis of a chiral monophosphorus ligand for the asymmetric addition of arylboronic acids to aryl aldehydes, providing a series of chiral diarylmethanols in excellent yields and enantioselectivities (up to 92% ee).Preliminary study has shown this process is catalyzed by a Ru complex with a single monophosphorus ligand.
其他文献
The indole alkaloids, ranging from lysergic acid to vincristine, have long inspired organic chemists.Interest in developing new methods for indole synthesis has burgeoned over the past few years.1 Usa
会议
Chalcones, pyrazoles and pyrimidine derivatives are known to be good antibacterial agents.[1] A series of pyrimidine analogues of triazole linked chalcone and pyrazole have been synthesized from 5-ace
会议
A chiral gold(Ⅰ) complex-catalyzed highly regio-and enantioselective azo hetero-Diels-Alder reaction has been developed.The chiral gold(Ⅰ) complex acting as a Lewis acid exhibits high efficiency in th
会议
A synthesis of 2-epi-fagomine via a highly stereoselective gold(Ⅰ)-catalyzed allene cyclization is described.The stereochemical outcome of the cyclisation is opposite to that observed in previous stud
会议
An enantioselective organocatalytic addition of nitroalkanes to oxindolylideneindolenines in the presence of bifunctional organocatalysts has been established to provide an efficient entry to 3,3-disu
会议
The first total synthesis of tubingensin A was finished starting from an advanced intermediate of anominine.The synthesis features a CuOTf-promoted 6π-electrocyclization/aromatization sequence to forg
会议
A gram scale approach was developed toward the advanced intermediate of taiwaniaquinoids.This intermediate 5a with trans A/B ring junction was concisely assembled by employing a Bi(OTf)3-catalyzed cat
会议
The stereoselective synthesis of spiro-tetrahydroquinolines has been realized via cacade hydrogenative dearomatization[1] of quinoline and aza-Friedel-Crafts reaction.This methodology features ready a
会议
We report an air-stable (π-allyl)iridium complex derived from dinaphthocyclooctatetraene and a phosphoramidite ligand.It was found highly efficient in iridium-catalyzed allylic substitution reactions.
会议
An efficient synthesis of enantioenriched tetrahydro-β-carbolines via chiral phosphoric acid catalyzed enantioselective transfer hydrogenation of hydroxylactams has been achieved.This methodology feat
会议