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Nikkomycins and polyoxins are nucleoside peptide antibiotics,which act as competitive inhibitors of fungal and insecticidal chitin synthases because of their structural similarity to UDP-N-acetylglucosamine.To get a novel compound with high biological activity or stability,combinatorial biosynthesis [1,2] was applied to nikkomycins and poiyoxins biosynthesis[3,4].Two active components with the hybrid nikkomycin-polyoxin structure were obtained:one was polyoxin N.