【摘 要】
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Background Lipopolysaccharide (LPS), an essential component of the outer membrane of Gram-negative bacteria,plays a pivotal role in the pathogenesis of myocardial contractile dysfunction in sepsis.CD7
【机 构】
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Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China
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Background Lipopolysaccharide (LPS), an essential component of the outer membrane of Gram-negative bacteria,plays a pivotal role in the pathogenesis of myocardial contractile dysfunction in sepsis.CD74, the main component of the cytokine maerophage migration inhibitory factor (MIF) receptor family, plays a crucial role in inflammatory diseases.Autophagy, a lysomal-dependent pathway of degradation, is responsible for the tumover of long-lived proteins and damaged or functionally redundant intracellular structures.A tie between autophagy and immune response has been reported, which may underlie LPS-induced cardiac dysfunction.
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