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PurposeTodescribethecomplicationsoccurredduringandaftertheirreversibleelectroporation(IRE)proceduresunderCT guidance. Methods Retrospectivelyanalyzed14IREacceptedpatients(4malesand10females,medianage,57years)withlocally advancedpancreatictumors(12withvascularinvasion)werenotamenabletointegrallysurgicalresection.Complicationswere recordedanddocumentedimmediatelyduringoraftertheprocedures,evenacoupleofdays(within3weeks)afterIRE. Result NoIREattributabledeathoccurred.Noperipheralvascularinjurywasfound.4patientsdevelopedlightnauseaand intermittentvomiting.3patientshadslightperipancreaticexudation.Mesentericandportalvenousthrombosiswasfoundon MRIimagesin4patients.1patientdevelopedretroperitonealinfection. Conclusion CT-guidedpercutaneousIREisaminimalinvasiveablationwithlow-riskofperipheralvascularinjuries.Identification ofpotentialcomplicationsandprocedure-relativedriskfactorscanallowoptimizationofperiproceduralmanagement.