Hypoxic preconditioning (HPC) is known to have a protective effect against hypoxic damage;however, the precise mechanisms involved remain unknown.In this study, an acute and repetitive hypoxia mouse m
人颗粒体蛋白是一种由外分泌糖基化多肽组成的蛋白家族,它具有12个半胱氨酸的保守结构域,来源于由7.5个颗粒体蛋白重复序列构成的颗粒体蛋白前体,颗粒体蛋白前体又称上皮蛋白前体,或PC细胞来源的生长因子.颗粒体蛋白的分子量约为6kDa,是颗粒体蛋白前体经酶解后的产物,这些酶解产物被命名为颗粒体A、B、C等,也被称为上皮蛋白1、2、3等,这些具有完整结构的颗粒体蛋白对细胞生长具有促进、抑制或者双向的调节
All-trans retinoic acid (ATRA) is a promising therapeutic agent, but exhibits low efficacy against human cancers.Sphingosine kinase (SphK), which catalyzes the phosphorylation of sphingosine to genera
Chemokine CXCL12 is an extracellular chemokine which binds to its cell surface receptor CXCR4.High expressions of CXCR4 and CXCL12 are associated with biological malignant potential in colon cancers.H
Rhodiola is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, eliminati
Deformities in the Circle of Willis (CoW) can significantly increase the risk of cerebrovascular disease in humans.However, the molecular mechanisms underlying these deformities have not been understo
Microsatellite instability (MSI) has been observed within tumors and found to be closely associated with the degree of malignancy and prognosis in tumors.However, whether MSI in tumor-related genes ca
Background: Most renal cell carcinoma (RCC) occur in one kidney;however, in a small set of patients (0.7-4.7%), RCCs occur in both kidneys (bilateral RCC).This particular type of RCC poses a challenge
Diabetes is a global public health problem and about 90% of which is type 2 diabetes mellitus (T2DM).To better understand the pathogenesis and potential therapeutic target, the animal models of T2DM a
Urotensin Ⅱ (UⅡ) and its receptor (UTR) have mitogenic effects on tumor growth.Our previous study demonstrated that the UⅡ/UTR system is up-regulated in dithyinitrosamineinduced precancerous rat liver