Breast cancer is one of the major causes of death among women in the world.Early diagnosis is surely very useful in saving lives, though not in all cases, it is not enough to prevent the disease.New diagnostic and treatment strategies are needed.Angiogenesis, the growth of new capillary blood vessels, is central to the growth of cancer.An understanding of the cellular and molecular basis of tumor angiogenesis is therefore important for clinicians who diagnose and treat cancer by whatever modalities.