【摘 要】
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Objective To study the correlation of 99mTc-HL91 imaging with HIF-1α expression for nasopharyngeal carcinoma (NPC).Method 12 patients with pathologically proven NPCs were enrolled into the study befor
【机 构】
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南昌大学第二附属医院 江西省肿瘤医院
【出 处】
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2015诺贝尔奖获得者医学峰会暨国际肿瘤研究高峰论坛
论文部分内容阅读
Objective To study the correlation of 99mTc-HL91 imaging with HIF-1α expression for nasopharyngeal carcinoma (NPC).Method 12 patients with pathologically proven NPCs were enrolled into the study before chemotherapy and radiotherapy.Local planar scans and SPECT acquisitions were performed at 1 and 4 hour after intravenous injection of 740-1110 MBq99mTc-HL91.Regions of interest (ROIs) were drawn around the tumor on planar and tomographic 99mTc-HL91 images.The tumor (T) to normal tissue (N) values (T/N) were counted.The expression of HIF-1α was determined by immunohistochemistry.
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