目的:探讨细菌外排泵抑制剂(microbial efflux pump Inhibitor,EPI)——维拉帕米对以血卟啉单甲醚(hematoporphyrin monomethylether,HMME)为光敏剂的光动力疗法(photo-dynamic therapy,PDT)杀灭牙菌斑生物膜内主要致龋菌的影响。方法:以变形链球菌、血链球菌、嗜酸性乳杆菌和粘性放线菌为实验菌株,建立牙菌斑生物膜模型。以维拉帕米 OBJECTIVE: To investigate the effect of verapamil on photo-dynamic therapy with hematoporphyrin monomethylether (HMME) as photosensitizer, PDT) to kill the major cariogenic bacteria in dental plaque biofilms. Methods: Streptococcus mutans, Streptococcus sanguis, Lactobacillus acidophilus and actinomycetes were used as experimental strains to establish the model of dental plaque biofilm. Verapamil