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AIM To compare the inhibitory effects of mangiferin and mangiferin sodium salt on influenza neuraminidase.METHODS Neuraminidase inhibitors screen kit was adapted to test mangiferin and mangiferin sodium salt.RESULTS IC50 (half maximal inhibitory concentration) of mangiferin and mangiferin sodium salt were 123.65 and 33.55 mg· L-1 , respectively.CONCLUSION Both mangiferin and mangiferin sodium salt have obvious inhibitory effects on influenza neuraminidase and the effect of mangiferin sodium salt was significantly stronger than that of mangiferin.