Analytical needs in the pharmaceutical industry presently include high throughput, high productivity and high resolution techniques.In high throughput, the aim is to obtain information, most often of a target solute, in the shortest possible time.Mass spectrometry is hereby the detector of choice because of its intrinsic selectivity.In high productivity separations the goal is to speed up analysis by a factor of 3 to 5 compared to the methods presently applied, but keeping the robustness intact.In high resolution techniques, time is not an issue as long as the highest degree of information on the composition of a complex sample is obtained.