【摘 要】
：
Hesperidin is a flavanone glycoside extracted from fruits of the genus citrus.For it poor solubility, our lab have synthesis a lot of derivatives.Previous studies were focus on the inflammation role o
【机 构】
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School of Pharmacy, Anhui Key Laboratory of Bioaetivity of Natural Products,Anhui Medical University
【出 处】
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中国药理学会生化与分子药理专业委员会2014年研讨会
论文部分内容阅读
Hesperidin is a flavanone glycoside extracted from fruits of the genus citrus.For it poor solubility, our lab have synthesis a lot of derivatives.Previous studies were focus on the inflammation role of hesperidin.However, the research on hepatic fibrosis is still rarely.Here, we screened one derivative of hesperidin that obvious influence the PDGF-BB-induced HSC-T6(a rat hepatic stellate cell line), then we investigated the anti-fibrotic effect of hesperidin derivative in HSC-T6 and in CC14 treatment induced mouse model of liver fibrosis.In vitro study was aimed to determine whether hesperidin derivative affects the survival of HSC-T6, while the in vivo study was designed to evaluate the anti-fibrotic efficacy of hesperidin derivative on CC14 induced liver fibrosis in Kunming mice.
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