In this study, chick chorioallantoic membrane (CAM) model with abundant blood vessels was developed to investigate the vascularization of porous calcium phosphate. Porous hydroxyapatite ceramic (HA) and calcium phosphate cement with segmental porous structure (CPCs) were implanted into CAM, respectively. Stereomicroscope and scanning electron microscope (SEM) were employed to observe the angiogenesis on the surface of CPCs. The vascular density, diameters and n mber were quantified by Image-Pro Plus and Nano Measurer. Furthermore, un-decalcified histological section was conducted to evaluate the inner angiogenesis of HA. Results revealed that porous structure played an important role on the angiogenesis. The stereomicroscope images showed that angiogenesis mainly occurred near the pores of CPCs after cultured for 6 d, although the blood vessels randomly grew along the edge of CPCs at initial stage. In porous part of CPCs, most of the blood vessels grew in budding manner and formed vascular network accompanied with the thrombus disappeared gradually as the increase of culture time. However, in the part without pores of CPCs, the angiogenesis was slow and vascular degeneration after cultured for 8 d. Quantitative data indicated that the percentage of vascular density in porous part of CPCs increased from 21.03 ± 2.58 % to 76.32 ± 4.63 %, while that in the part without pores of CPCs reduced from 78.97 ± 2.58 % to 23.68 ± 4.63 %. The present results indicated that angiogenesis mainly appeared in porous part at later cultured stage. SEM results showed that blood vessels grew tightly on the surface of CPCs. Histological section demonstrated that blood vessels grew into the inside of HA along with the extended loose connective tissue. In summary, three-dimensional porous structure is beneficial to the angiogenesis. CAM model is convenient, efficient and with low-cost to research the vascularization of porous calcium phosphate, which can provide a new way for the evaluation of vascularization of implant.