【摘 要】
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Successful controlled release for intracellular delivery requires both sufficient cellular uptake and suitable internalization pathways.With superior cellular uptake capacity and potentially direct tr
【机 构】
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Department of Chemical and Biomolecular Engineering,The Hong Kong University of Science and Technolo
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Successful controlled release for intracellular delivery requires both sufficient cellular uptake and suitable internalization pathways.With superior cellular uptake capacity and potentially direct transduction mechanism,cell-penetrating peptide has gained much attention in the past years.Among cell-penetrating peptides,oligoarginine has been widely used and has successfully delivered various cargoes to reach their intracellular targets.However,oligoarginine as well as other cell-penetrating peptides have disadvantages such as low drug carrying capacity and weak cargo protection.Therefore,we introduced this peptide into biodegradable polymeric nanoparticles through surface modification,to increase payload,protect the cargo and prolong the release.Since the information towards the internalization mechanism for particles with different modifications was still limited,we also focused on studying how the length and density of oligoarginine on the polymeric particle surface can affect its cellular uptake as well as internalization mechanism.
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