【摘 要】
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Background: Necrotic enteritis (NE), caused by Clostridium perfringens, has cost the poultry industry $2 billion in losses.This study aimed to investigate the effect of Bacillus licheniformis as dieta
【机 构】
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Animal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chen
【出 处】
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中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
论文部分内容阅读
Background: Necrotic enteritis (NE), caused by Clostridium perfringens, has cost the poultry industry $2 billion in losses.This study aimed to investigate the effect of Bacillus licheniformis as dietary supplement on the growth,serum antioxidant status, and expression of lipid-metabolism genes of broiler chickens with C.perfringens-induced NE.Methods: A total of 240 one-day-old broilers were randomly grouped into four: a negative control, an NE experimental model (PC), chickens fed a diet supplemented with 30% of fishmeal from day 14 onwards and challenged with coccidiosis vaccine (FC), and NE group supplied with feed containing 1.0 × 106 CFU/g B.licheniformis (BL).Results: Body weight gain, feed conversion ratio, serum antioxidant status, and lipid-metabolism-gene expression were analyzed.In the PC group, FCR increased significantly whereas serum catalase and glutathione peroxidase activity decreased compared with NC group.Dietary B.licheniformis supplementation improved FCR and oxidative stress in experimental avian NE.Using Bacillus licheniformis, is as a direct-fed microbial (DFM) could also significantly upregulate catabolism-related genes,namely, peroxisome proliferator-activated receptor-α and carnitine palmitoyltransferase-1, in livers and changed the expression of lipid-anabolism genes.Conclusion: These results suggested that dietary B.licheniformis supplementation can enhance growth and antioxidant ability, as well as change the expression of genes related to fatty-acid synthesis and oxidation in the livers of NE-infected broilers.
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