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As an adhesion molecule, β1, 4-galactosyltransferase-1 (GalT) plays a crucial role in the development and progression of cancer.The role of GalT on invasive ability of endometrial carcinoma has not been elucidated.Hence, we investigated the effect of GalT on invasion in HEC-1A cells and RL95-2 cells.GalT level was detected by RT-RCR, Western blot and immunofluorescence.