【摘 要】
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Aims We have previously shown that single nucleotide polymorphisms (SNPs) at C161T in the peroxisome proliferator-activated receptors-γ (PPAR-γ) gene were associated with the susceptibility to non-alc
【机 构】
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Guangzhou First Peoples Hospital
【出 处】
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中华医学会第十六次全国病毒性肝炎及肝病学术会议
论文部分内容阅读
Aims We have previously shown that single nucleotide polymorphisms (SNPs) at C161T in the peroxisome proliferator-activated receptors-γ (PPAR-γ) gene were associated with the susceptibility to non-alcoholic fatty liver disease (NAFLD) (Liver Int.2008, 28 ; 385).In this study, we further investigated the effect of the SNPs at three other loci in PPAR-γ gene i.e.C-681G, C-689T and Pro12Ala on the susceptibility to NAFLD.Methods The subjects were selected from an epidemiological survey in Guangdong province of southern China.169 subjects who met the diagnostic criteria of NAFLD and had typical clinical and ultrasonographic findings were enrolled in the NAFLD group, and 699 healthy subjects were included as controls.Polymerase chain reaction and restriction fragment length polymorphism.(PCR-RFLP) was applied to detect the SNPs at the three loci.Single-variant-and haplotype-based analyses were performed to analyze the results.
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