【摘 要】
：
Associating genotype to phenotype at the molecular level is always a challenge.In "the Informational (Genetic) Word" all relationships are described in DNA
【机 构】
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BeijingInstituteofGenomics,ChineseAcademyofSciences
【出 处】
：
第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
Associating genotype to phenotype at the molecular level is always a challenge.In "the Informational (Genetic) Word" all relationships are described in DNA sequence and its terms for genotypes so that the solution is by definition partial.It is now overwhelmingly replaced by "the Dynamic World" and to decipher the multiple equations of lifes physiological activities,which assume two unknowns-genetics and epigenetics,is of urgency.In such a real biological world,our first effort concerns convergence that focuses on the unification of concepts and terms from four clusters of disciplines,including (1) medicine (such as physiology and anatomy),(2) molecular biology (such as cell biology and biochemistry),(3) genetics (such as population genetics and molecular evolution),and (4) genomics (such as systems biology and bioinformatics).The next effort is to focus on further stratification of biological essentials in minimal layers that may include information,operation,homeostasis,compartmentalization,and plasticity,where molecular mechanisms and cellular processes are to be described,in mechanoehemical and spatiotemporal parameters.
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